Tirthaj Adhikari is a researcher in medical physics with a specialization in computational dosimetry and brachytherapy physics. His work focuses on enhancing Model-Based Dose Calculation Algorithms (MBDCA) for low-energy brachytherapy applications, particularly involving Cesium-131 (Cs-131) sources.
His research integrates Monte Carlo simulations, dose modeling in heterogeneous media, and experimental validation, aiming to improve the precision of patient-specific dose assessments beyond conventional TG-43 formalism.
His long-term goal is to advance the clinical adoption of model-based dosimetry approaches to achieve more accurate, individualized treatment planning in low-energy photon brachytherapy.
Research Interests
- Model-Based Dose Calculation Algorithms (MBDCA)
- Low-Energy Photon Brachytherapy (Cs-131, I-125, Pd-103)
- Monte Carlo Simulation for Medical Applications (MCNP)
- Dosimetric Characterization and Uncertainty Quantification
- Heterogeneity Correction and Patient-Specific Dose Modeling
- Radiobiological Modeling and Clinical Dose Optimization
Current Research Project
Title: Enhancement of Model-Based Dose Calculation Algorithms for Cs-131 Brachytherapy Dosimetry for intracranial lesions using Monte Carlo m-particle.
His project focuses on the refinement of computational dosimetry techniques to accurately represent the dose distribution from Cs-131 sources in realistic anatomical environments.
Objectives include:
- Developing high-resolution voxel-based dose models using Monte Carlo methods.
- Benchmarking MBDCA-derived doses against TG-43 formalism under various tissue and material conditions.
- Implementing heterogeneity corrections and validating dose distributions with phantom studies.
Facilitating integration of improved MBDCA kernels into clinical treatment planning systems.
Recent Publication: https://www.sciencedirect.com/science/article/pii/S1538472125000364
